After numerous tests I can say that files with paper size A4 can be published to PDF with WP21 without problem. The problem I mentioned before (Acrobat reporting that the dimensions of this page lie outside of the permitted range) occurs regularly with all (!) my files with paper size 15,24cm by 22,86cm and binding width left 0,68cm. It seems that the Publish to PDF function in WP21 cannot handle this paper size.